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BeKm-1
簡(jiǎn)要描述：Smartox Biotechnology是*一家專門生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：13BEK001- 廠商性質(zhì)：代理商
- 更新時(shí)間：2025-07-02
- 訪 問(wèn) 量：1482
產(chǎn)品介紹
BeKm-1
Selective blocker of ERG1 channel(鉀通道ERG1選擇性阻斷劑)
BeKm-1 toxin is a peptide toxin that has been isolated from the venom of the Central Asian scorpion Buthus eupeus. toxin has been reported to be a highly selective inhibitor of the human ether-a-go-go ERG1 channel (hERG1) . inhibits hERG1 channels expressed in HEK-293 cells with an IC50 of 3.3 nM, but has no effect at 100 nM on human EAG, human SK1, rat SK2, human IK, human BK, KCNQ1/KCNE1, KCNQ2/KCNQ3, and KCNQ4 channels. It has also minimal effects on rat ELK1 channel. inhibits the human ERG1 + KCNE1 combination transiently expressed in HEK-293 cells with an IC50 value in the range of 10 to 30 nM. toxin preferentially blocks human ERG channel through the closed (resting) state, although some open channel blockade is also reported to occur.
技術(shù)資料
氨基酸序列：
Arg-Pro-Thr-Asp-Ile-Lys-Cys7-Ser-Glu-Ser-Tyr-Gln-Cys13-Phe-Pro-Val-Cys17-Lys-Ser-Arg-Phe-Gly-Lys-Thr-Asn-Gly-Arg-Cys28-Val-Asn-Gly-Phe-Cys33-Asp-Cys35-Phe-OH
二硫鍵：Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35
長(zhǎng)度 (aa)： 36
分子式： C174H261N51O52S6
分子量：4091.70 Da
外觀： White lyophilized solid
可溶性：water and saline buffer
CAS 號(hào)：Not available
來(lái)源： Synthetic
純度： > 97%
產(chǎn)品信息
13BEK001-00100 | 0.1mg | |
13BEK001-00500 | 0.5mg |
